Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites

@article{Stephens.Schneider-splice1992,
author = "R. M. Stephens
 and T. D. Schneider",
title = "Features of spliceosome evolution and function inferred from
an analysis of the information at human splice sites",
journal = "J. Mol. Biol.",
volume = "228",
pages = "1124--1136",
pmid = "1474582",
note = "\htmladdnormallink
{https://doi.org/10.1016/0022-2836(92)90320-j}
{https://doi.org/10.1016/0022-2836(92)90320-j}",
\htmladdnormallink
{https://alum.mit.edu/www/toms/papers/splice/}
{https://alum.mit.edu/www/toms/papers/splice/}",
year = "1992"}

On 2005 Aug 29 I learned that we should have cited two papers:

EMBO J. 1989 Jul;8(7):2015-21. Evidence that introns arose at proto-splice sites. Dibb NJ, Newman AJ. (pubmed)
J Theor Biol. 1991 Aug 7;151(3):405-16. Proto-splice site model of intron origin. Dibb NJ. (pubmed)

Dibb had already noticed the similarity of the donor and acceptor sites, but we didn't know about his paper! Our fault. Interestingly, because the consensus sequences are the same on the acceptor and donor sites but the information curves are very different, we invented logos to explain this case!

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Schneider Lab
origin: 1996 Feb 20
updated: 2021 Jan 25
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