Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites

sequence logo of splice donor

@article{Stephens.Schneider-splice1992,
author = "R. M. Stephens
 and T. D. Schneider",
title = "Features of spliceosome evolution and function inferred from
an analysis of the information at human splice sites",
journal = "J. Mol. Biol.",
volume = "228",
pages = "1124--1136",
pmid = "1474582",
note = "\htmladdnormallink
{https://doi.org/10.1016/0022-2836(92)90320-j}
{https://doi.org/10.1016/0022-2836(92)90320-j}",
\htmladdnormallink
{https://alum.mit.edu/www/toms/papers/splice/}
{https://alum.mit.edu/www/toms/papers/splice/}",
year = "1992"}

sequence logo of splice acceptor



On 2005 Aug 29 I learned that we should have cited two papers: Dibb had already noticed the similarity of the donor and acceptor sites, but we didn't know about his paper! Our fault. Interestingly, because the consensus sequences are the same on the acceptor and donor sites but the information curves are very different, we invented logos to explain this case!

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Schneider Lab

origin: 1996 Feb 20
updated: 2020 Oct 22
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