fff: Molecular Flip-Flops Formed by Overlapping Fis Sites

fff: the paper
- BiBTeX reference:
```
@article{Hengen.Schneider2003,
author = "P. N. Hengen
 and I. G. Lyakhov
 and L. E. Stewart
 and T. D. Schneider",
title = "Molecular Flip-Flops Formed by Overlapping {Fis} Sites",
journal = "Nucleic Acids Res.",
volume = "31, No. 22",
pages = "6663-6673",
year = "2003"}
```
- Pubmed
- Offical versions at Nucleic Acids Research:
  - Abstract: Molecular Flip-Flops Formed by Overlapping Fis Sites
  - Full Text: Molecular Flip-Flops Formed by Overlapping Fis Sites
- My preprints:
  - Molecular Flip-Flops Formed by Overlapping Fis Sites
    PostScript version
  - Molecular Flip-Flops Formed by Overlapping Fis Sites
    PDF version
- Proposed cover figure (not used)
fff: the patent: Molecular Computing Elements: Gates and Flip-Flops
fff: the PostDoc position
See also the previous paper: Information analysis of Fis binding sites

If you need background information about information theory you can explore my web site. You may find these two resources particularly useful:

Information Theory Primer, With an Appendix on Logarithms
A Glossary for Molecular Information Theory and the Delila System.
A good starting point would be the definition of a bit.

Tom Schneider

3 Dimensional Models

At one point I had the monomer model printed out in 3D on a Z corp printer (http://www.zcorp.com/) and unfortunately one can observe a gap in the backbone phosphate-sugars. Presumably this could be fixed by relaxing with a molecular dynamics program. If you do, I'd be interested in a revised model!

Related References

Hasty J, McMillen D, Collins JJ. Engineered gene circuits. Nature. 2002 Nov 14;420(6912):224-30. Review. PubMed PMID: 12432407
Isaacs FJ, Hasty J, Cantor CR, Collins JJ. Prediction and measurement of an autoregulatory genetic module. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7714-9. Epub 2003 Jun 13. PubMed PMID: 12808135

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Schneider Lab
origin: 2003 October 14
updated: 2013 Apr 04
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