p53: Discovery of novel tumor suppressor p53 response elements
using information theory

@article{Lyakhov.Schneider-p53-2008,
author = "I. Lyakhov
 and K. Annangarachari
 and T. D. Schneider",
title = "{Discovery of Novel Tumor Suppressor p53 Response
Elements Using Information Theory}",
journal = "Nucleic Acids Res.",
volume = "36",
pages = "3828--3833",
pmid = "18495754",
year = "2008"}

• PubMed entry
• Links at Nucleic Acids Research:
  • Abstract
  • Full Text
  • PDF
  • Supplementary material
  • Article Data Webpage
• Talk: p53talk.pdf p53talk.ppt
• Poster presentation: p53poster.pdf
• Our prediction that CLCA2 is under p53 control was confirmed by three laboratories!
  • CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion.
    Sasaki Y, Koyama R, Maruyama R, Hirano T, Tamura M, Sugisaka J, Suzuki H, Idogawa M, Shinomura Y, Tokino T.
    Cancer Biol Ther. 2012 Dec;13(14):1512-21. doi: 10.4161/cbt.22280.
    PMID: 22990203
  • CLCA2 as a p53-inducible senescence mediator.
    Tanikawa C, Nakagawa H, Furukawa Y, Nakamura Y, Matsuda K.
    Neoplasia. 2012 Feb;14(2):141-9.
    PMID: 22431922
  • hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation.
    Walia V, Ding M, Kumar S, Nie D, Premkumar LS, Elble RC.
    Cancer Res. 2009 Aug 15;69(16):6624-32. doi: 10.1158/0008-5472.CAN-08-4101.
    PMID: 19654313

The fasta files are the data from the original papers. The sequence logos were generated from the aligned sequences. The sequence walker lister map were made using our natural p53 model scanned over the sequences.

Other pointers:

• Primer on information theory
• A Glossary for Molecular Information Theory and the Delila System. A good starting point would be the definition of a bit.

Tom Schneider

Schneider Lab
origin: 2008 May 22
updated: 2014 Jan 05 CLCA2 prediction confirmed!