• Patent 5,867,402 issued 1999 Feburary 2:
  Computational analysis of nucleic acid information defines binding sites
  Thomas D. Schneider and Peter K. Rogan
  at the United States Patent and Trademark Office.

  • The patent describes a method called 'individual information' which allows one to calculate the information for individual DNA, RNA or protein binding sites. There is a corresponding graphic called a 'sequence walker'. The method allows one to measure the sequence conservation of the binding sites. A major use is to analyze Single Nucleotide Polymorphisms (SNPs - single base changes in the sequence) of RNA splice junctions to determine if they cause genetic diseases.

  • United States Patent 5867402 at www.freepatentsonline.com
  • United States Patent 5867402 at www.patentlens.com
  • US Patent office, http://www.uspto.gov/
  • www.delphion.com

• The example given below shows the effect of a mutation that causes blindness, found by R. Allikmets and M. Dean.
  

• Sequence Walkers Glossary definition

• Individual Information Theory and Sequence Walkers General information about sequence walkers

• NON-CONFIDENTIAL PATENT DESCRIPTION

• Related patent:

  • US5849492: Method for rapid identification of prokaryotic and eukaryotic organisms Rogan, Peter K.; Lebanon, PA,
  • US Patent office, http://www.uspto.gov/
  • www.delphion.com

• Email contact

• This technology is available as open source.

Schneider Lab
origin: 2000 April 27
updated: 2022 Aug 01