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Pluchino.Gottesman2015: Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA

author = "K. M. Pluchino
 and D. Esposito
 and J. K. Moen
 and M. D. Hall
 and J. P. Madigan
 and S. Shukla
 and L. V. Procter
 and V. E. Wall
 and T. D. Schneider
 and I. Pringle
 and S. V. Ambudkar
 and D. R. Gill
 and S. C. Hyde
 and M. M. Gottesman",
title = "{Identification of a Cryptic Bacterial Promoter in Mouse
(\emph{mdr1a}) P-Glycoprotein cDNA}",
journal = "PLoS One",
volume = "10",
pages = "e0136396",
pmid = "26309032",
year = "2015"}

S1 Fig. Putative sigma 70 promoter and ribosome binding sites in mouse mdr1a cDNA.

The coordinate system begins at the first base of the mdr1a coding region. For the first two sequences, flexible individual information models for E. coli sigma70 (yellow, red rectangular petals) and extended -10 sigma70 (green) and ribosome binding sites (purple and blue) were scanned over the sequence and displayed using sequence walkers. The third sequence shows the effect of changing base 319 from an A to a C in M107L. This lowers the initiation codon from 6.3 bits to -5.5 bits, effectively removing the ribosome binding site. https://doi.org/10.1371/journal.pone.0136396.s001 (PDF)

Figure S1 showing how a base change
in mouse mdr1a makes a ribosome binding site

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origin: 2020 Feb 01
updated: version = 1.00 of Pluchino.Gottesman2015.html 2020 Feb 01

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