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Elements in the λ Immunity Region Regulate Phage Development: Beyond the `Genetic Switch'  
plit-oop-cover
Two σ70 promoters of bacteriophage λ are controlled by the LexA SOS reglulon, pLit and pOop. These promoters are displayed using sequence walkers. Blue rectangles are are behind -35 elements and red rectangles are behing the -10 of the promoters. These elements are connected by a rainbow colored bar. Purple rectangles are behind the LexA walkers. (This figure was proposed as the cover of the journal but not used.)
  

@article{Thomason.Court2019,
author = "L. C. Thomason
 and K. Morrill
 and G. Murray
 and C. Court
 and B. Shafer
 and T. D. Schneider
 and D. L. Court",
title = "{Elements in the λ Immunity Region Regulate
Phage Development: Beyond the ``Genetic Switch''}",
journal = "Mol Microbiol",
volume = "112",
pages = "1798--1813",
pmid = "31545538",
note = "\htmladdnormallink
{https://doi.org/10.1111/mmi.14394}
{https://doi.org/10.1111/mmi.14394}",
year = "2019"}
 
plit-oop-graphical-abstract

Accessory elements in the phage λ immunity region include rexA, rexB and the PLIT promoter; these elements modulate bacteriophage development as λ switches from lysogenic to lytic growth. PLIT transcribes only rexB and is repressed by the Escherichia coli LexA repressor. DNA damage inactivates the LexA and λ CI repressors, causing RexB expression to increase as λ switches to lytic development. Lytic growth is compromised if the level of RexB relative to RexA is reduced.

Background Papers

Permanent link https://alum.mit.edu/www/toms/papers/Thomason.Court2019/ points to the current web location.

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Schneider Lab
origin: 2019 Feb 14
updated: version = 1.01 of Thomason.Court2019.html 2019 Dec 11

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